Perfusion imaging is a term used to describe functional imaging techniques used in quantifying hemodynamics. In 2015 a Hybrid-OR was opened as part of the Medical Innovation and Technology Expert Center (MITeC) at the Radboud University Medical Center. This room setting is utilized for minimal invasive and/or surgical procedures supported by MR, CT or X-ray intervention technologies. In multiple projects, we test new peri- and intra-operative diagnostic imaging techniques with a multidisciplinary approach.
1. Magnetic Resonance Imaging techniques in patients with Refractory Critical Limb ischemia
Patients with atherosclerosis of the large arteries in the leg can develop end-stage ischemic limb disease. Despite several diagnostic tools, accurately assessing tissue viability and predicting outcomes after (vascular) interventions proves to be difficult.
In this study, we will compare three methods for the (in)direct measurement of tissue perfusion: transcutaneous oxygen measurement, Blood Oxygenation Level-Dependent (BOLD) MRI, dynamic contrast-enhanced (DCE)-MRI. By providing an accurate predictor we aim to improve diagnostics and guide patients to the appropriate treatment.
2. Circulation and Hemodynamics in Living Donation of Kidney Transplantation in Children
Kidney transplantation with a living donor provides the best long term outcome for children with end-stage renal failure. Transplanting an adult sized kidney can result in a donor-recipient size mismatch and may cause relative hypoperfusion with possible loss of kidney mass and graft function.
Main goals of this study are 1) providing insight in hemodynamic responses after pediatric kidney transplantation and 2) testing a new application using this non-invasive technique without the use of radiation and nefrotoxic contrast materials.
3. Cerebral perfusion imaging in neurosurgery – of neurosurgery
Flat panel detector computed tomography technology mounted on a robotic C-arm allows for intra-operative imaging during neurosurgery. Applying perfusion imaging with this CT-based technique enables assessing cerebral hemodynamics in an OR setting.
Testing this new technique in a small feasibility study is the first step towards potential neurosurgical applications like intra-operative feedback in craniotomy or image guided interventions.
These projects are executed in close collaboration with Siemens Healthineers, Germany.